Surgical excision should be considered for patients with good performance status, minimal or no evidence of extracranial disease, and a surgically accessible single brain metastasis amenable to complete excision. Since treatment in this disease is considered palliative, invasive local treatments must be individualized. Patients with lesions requiring emergency decompression due to intracranial hypertension were excluded from the randomized control trials but should be considered to be surgical candidates.
Postoperative whole brain radiotherapy (WBRT) should be considered to reduce the risk of tumour recurrence for patients who have undergone resection of a single brain metastasis. The optimal dose and fractionation schedule for whole brain radiation therapy is 3,000 cGy in 10 fractions or 2,000 cGy in five fractions.
Stereotactic radiosurgery (SRS) boost should be considered following WBRT for patients with single metastases. There is insufficient evidence to recommend SRS alone as single modality therapy.
加拿大安大略癌症治疗中心(CCO,Cancer Care Ontario)是致力于不断改善癌症服务的省级机构,同时为政府的癌症顾问,主要任务包括指导和监督医院和其他组织提供高质量及时的癌症服务;执行省级的癌症预防和筛查方案;与专业人员和组织一起制定和实施质量改进和标准;推进癌症临床实践的改进和创新等等。